Research & Development

Research & Development

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Synergene R&D, established in 2007, has a team of experienced professionals dedicated to driving innovation and excellence in API research and development. A robust analytical R&D department equipped with state-of-the-art instruments, including LCMS, GCMS and UPLC for accurate and reliable analytical evaluations

Core responsibilities

  • Genotoxic Impurity Evaluation: Comprehensive assessment of genotoxic impurities immediately after process optimization, ensuring detection limits are established at the appropriate stages
  • Sustainable Practices: Emphasizing the recovery and reuse of solvents, reagents, and catalysts to enhance process capability, reduce waste, and support sustainability initiatives
  • Process Robustness: Establishing and monitoring critical process parameters with a well-defined mitigation plan to effectively address any process deviations and maintain consistency
  • Reaction capabilities: Grignard reaction, Asymmetric reduction, N-Butyl Lithium, Chemical resolution , High pressure hydrogenation and Amination, Halogen exchange /Substitutions, Michael additions, Re-arrangements, Coupling reactions, Acylations, Azide reactions, Esterification

Achievements

  • Granted Indian Patent - “Improved process for the preparation of Escitalopram Oxalate”
  • Granted Indian Patent - “Improved process for the preparation of S (+) Dapoxetine Hydrochloride”
  • Granted Indian Patent - “A process for the preparation of luliconazole”