SYNERGENE ACTIVE INGREDIENTS PVT.LTD.
Systematic Approach For Innovation

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INTERMEDIATES

Afatinib Intermediates

Product Name CAS No. Structure
(S)-N4-(3-chloro-4-fluorophenyl)
-7-(tetrahydrofuran-3-yloxy)
quinazoline-4,6-diamine
314771-76-1
trans-4-Dimethylaminocrotonic acid hydrochloride 848133-35-7
N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine 162012-67-1
Imatinib Intermediates
N-(2-Methyl-5-nitrophenyl)-4- (pyridin-3-yl)pyrimidin-2-amine 152460-09-08
N-(5-Amino-2-methylphenyl)-4-/-)3-pyridyl)-2-pyrimidineamine 152460-10-1
4-(4-Methyl-piperaziro) Methyl Benzoic Acid 106261-48-7
Ibrutinib Intermediates
5-Amino-3-(-4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 3300792-7-6
Solifenacin Intermediates
(s)-1-phenyl-1,2,3,4-tetrahydro isoquinoline 118864-75-8
Pemetrexed Intermediates
4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pymol[2,3-d] pyrirnodin-5yl) ethyl] benzoic acid 137-281-39-1
Systematic Approach for Innovation
None of the products will be supplied to countries in which this could be in conflict with existing patents.
Further, any products under patent will be offered or R&D purpose only. However the final responsibility lies exclusively with the buyer

Gefitinib Intermediates

Product Name CAS No. Structure
7-methoxy-6-(3morpholin-4-ylpropoxy)quinazolin-4-(3h)-one 199327-61-2
Methyl 5-hydroxy-4-methoxy-2- nitrobenzoate 31839-20-0
(7-methoxy-4-oxo-1H- quinazolin-6-yl) acetate 179688-53-0
Amiloride intermediates
3-Aminopyrazine-2-carboxylic Acid 5424-01-01
Olmesartan intermediates
4-(1-Hydroxy-1-methylethyl)-2-propl-1H- imidazole-s -carboxlic acid ethyl ester 144689-93-0
Dolutegravir Intermediates
Amino Acetaldehyde dimethyl acetal 22483-09-6
Methyl-4-Methoxy
Acetoacetate
41051-15-4
Prazosin/ Terazosin/ Doxazosin/ Alfuzosin Intermediates
4-Amino-2-chloro-6,7-dimethoxy
Quinazoline
23680-84-4
Fluconazole intermediates
2(2,4 Diflurophenyl)-1-(4-amino)-1H-1,2,4-triazole-1-yl)-ethanone
Hydrochloride
Systematic Approach for Innovation
None of the products will be supplied to countries in which this could be in conflict with existing patents.
Further, any products under patent will be offered or R&D purpose only. However the final responsibility lies exclusively with the buyer

Fluconazole intermediates

Product Name CAS No. Structure
1-((2,4-Diflurophenyl)-1-(1H-1,2,4-triazole-1yl)_ethanone(DFTA) 86404-63-9
2-(2,4-Diflurophenyl)-1- (1H-1,2,4-triazole-1yl)
2,3 Epoxy propane-Methane sulphonate (EPOXY MESYLATE)
6386-77-8
Voriconazole Intermediates
2_(1H-1,2,4 Triazol-1-yl)-2,
4-difluoro acetophenone
86404-63-9
6-(1-Bromo ethyl)-4-chloro-5- fluoro pyrimidine 188416-28-6
(2R,3s/2s, 3R)-3-(5-fluoropyrimidyin-4-yl-2-(2,4-difluorophenyl)
-1-(1H-1,2,4 triazol-1-yl) butan-2-ol (racemic voriconazole)
188416-29-7
(2R,3s)-2-(2,4-Difluorophenyl)-3-(5-fluoro Pyrimidine-4yl)-1
-(1H-1,2,4 triazol-1-yl) butan-2-ol camphor sulfonate
137234-71-0
Efinaconazole Intermediates
4-methylene piperidine 148133-82-8
1-(((2r,3S)-2-(2,4-difluorophenyl)-3-methloxiran-
2-yl)methyl)-1H-1,2,4-triazole
188416-29-7
Terbinafine Intermediates
6,6 Dimethylhept-1-en-4-yn-3-ol 78629-20-6
Systematic Approach for Innovation
None of the products will be supplied to countries in which this could be in conflict with existing patents.
Further, any products under patent will be offered or R&D purpose only. However the final responsibility lies exclusively with the buyer

Terbinafine Intermediates

Product Name CAS No. Structure
Trans-1-Chloro-6,6-dimethylhept- 2-en-4-yne 83554-69-2
N-(1-Naphthyl methyl)methyl
amine Hydrochloride
65473-13-4
N-(1-Naphthyl methyl) methyl amine (Free Base) 14489-75-9
(2E) N,6,6-Trimethyl-N- (naphthalen-1-ylmethyl
hept-2-en-4-yn-1-amine(Terbinafine Base)
91161-71-6
Citalopram & Escitalopram Oxalate intermediates
4-[(4-Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl-
3-(hydroxymethyl)- benzonitrile (Diol base)
103146-25-0
4-[(4-Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl] -3 hydroxy methyl
benzonitrile Hydrochloride
717133-25-0
4-[(4-dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-
butyl]-3 hydroxy methyl benzonitrile Hydrochloride
103146-26-5
4-[(4-Dimethylamino)0-1-(4-fluorophenyl)-1-hydroxybutyl]
-3- (hydroxymethyl)-benzonitrile D-hemi tartaricacid salt
128173-53-5
Lasartan Potassium Intermediates
2-Butyl-4-chloro-1-[[(2'-(1 H-tetrazole-5-yl
(1,1'-biphenyl)-4yl]methyl]-1H
imidazole-5-methanol(losartan)
114798-26-4
Dapoxetine Intermediates
N,N-Dimethyl-1-phenyl-3-(1-napthalenyloxy)
propanamine oxalic acid salt (Racemic Dapoxetine oxalate)
Systematic Approach for Innovation
None of the products will be supplied to countries in which this could be in conflict with existing patents.
Further, any products under patent will be offered or R&D purpose only. However the final responsibility lies exclusively with the buyer

Dapoxetine Intermediates

Product Name CAS No. Structure
(+)-N,N-Dimethyl-1-phenyl-3- (1-napthalenyl oxy)
propanamine (Dapoxetine free base)
119356-77-3
Racemic Dapoxetine HCI 1071929-03-7
Racemic Dapoxetine 119356-76-2
S-Amlodipine Besylate Intermediates
S-Amlodipine Base 103129-82-4
Zafirlukast Intermediates
5- Nitro indole 6146-52-7
Methyl 4-(5-Amino-1-Methyl indol-3-yl
Methyl)-3-Methoxy Benzoate
107754-14-3
Sumatriptan Succinate Intermediates
3-[2-Aminoethy]-N-methyl-1
H indole-5-methane
sulfonamide (Suma stage 1)
88919-22-6
4-Hydrazino-N-methylbenzene methane
sulfonamide HCI (HMBS)
88933-16-8
4-Chlorobutyraldehydesodiumbisulfite
(ADDUCT)
54322-20-2
4-(N,N-Dimethylamino)
butane diethyl acetal
1116-77-4
Systematic Approach for Innovation
None of the products will be supplied to countries in which this could be in conflict with existing patents.
Further, any products under patent will be offered or R&D purpose only. However the final responsibility lies exclusively with the buyer

Midazolam Intermediates

Product Name CAS No. Structure
8-chloro-6-(2-fluorophenyl)-1-methy-
4H-imidazol [1,5-a]benzodiazepine-3-
Carboxylic acid
59468-44-9
Rivastigmine Intermediates
(s)-[1-(3-hydoxypheny)ethyl)
Dimethylamine
139306-10-8
3-(1-(Dimethylamino)
Ethyl]phenol
105601-04-5
Rivaroxaban Intermediates
4-(4-Aminophenyl)morpholin-3-one 438056-69-0
(S)-(+)-N-(2,3-Epoxypropyl)phthalimide 161596-47-0
Other Intermediates
Diethyl 2-(2-(2,4-difluorophenyl)
allyl)malonate
159276-62-7
2-(2-(2,4-difluorophenyl)
propane-1,3-diol
165115-73-1
2-chloro-1-(2,4-difluorophenyl)
ethan-1-one
51336-94-8
Systematic Approach for Innovation
None of the products will be supplied to countries in which this could be in conflict with existing patents.
Further, any products under patent will be offered or R&D purpose only. However the final responsibility lies exclusively with the buyer