Chemistry and Reactions

At Synergene, our four decades of industrial experience empower us to handle highly complex and specialized chemical reactions safely, efficiently, and at scale. Our expertise forms the backbone of our ability to develop and manufacture high-quality APIs, Intermediates, and Specialty Chemicals for our global partners.

Our state-of-the-art facilities and experienced scientific teams allow us to execute a wide variety of challenging chemistries, from route scouting and proof-of-concept in the lab, all the way to multi-ton commercial manufacturing.

Hydrogenation and Catalytic Reductions

We are highly proficient in conducting catalytic hydrogenation reactions (both homogeneous and heterogeneous) in strictly controlled, inert environments. Our facilities are equipped with specialized high-pressure autoclaves capable of supporting specific hydrogenation processes and complex reduction reactions from pilot (5-10 kg) to large-scale commercial batches.

Cryogenic Reactions

Handling ultra-low temperatures safely while maintaining product integrity is a core strength. We possess dedicated cryogenic reactor facilities designed to handle air- and moisture-sensitive reactions at temperatures as low as -80 °C. This allows us to perform highly selective chemistries and lithiation reactions at scalable volumes.

Cyanation and Halogenation

Synergene has specialized infrastructure dedicated to hazardous chemistries, including cyanation, bromination, and chlorination. Our facilities feature advanced containment, robust process safety controls, and well-established quenching and effluent treatment procedures to ensure these complex reactions are performed safely at commercial scale.

Chiral Synthesis and Resolution

We specialize in the development and scale-up of diverse chiral synthesis and resolution methods. Recognizing the critical importance of stereochemistry in modern APIs, our team ensures the establishment of optimal, cost-effective routes to produce enantiopure pharmaceuticals with exacting optical purity, scaling seamlessly from grams in the lab to hundreds of kilograms in manufacturing.

Organometallic Chemistry and Cross-Coupling

Our synthetic labs and manufacturing units are equipped with specific reactors to safely handle air-sensitive reagents required for organometallic carbon-carbon and carbon-heteroatom bond formations. We have extensive experience scaling up transition-metal-catalyzed cross-couplings (such as Suzuki, Heck, and Sonogashira reactions) crucial for synthesizing complex modern APIs.

Heterocyclic and Specialty Chemical Synthesis

Leveraging our deep expertise in specialty chemicals, we offer comprehensive capabilities in synthesizing complex heterocyclic building blocks and advanced intermediates. Our flexible manufacturing blocks are designed to produce customized solutions for intricate heterocyclic compounds, serving both captive API consumption and external client needs.

Supply Chain Management

Learn how our robust global distribution network ensures the secure, timely, and uninterrupted delivery of APIs and intermediates to partners across more than 50 countries.

Quality Control & Assurance

Discover our zero-compromise approach to quality and how our stringent protocols guarantee compliance with the highest global regulatory and pharmacopeial standards.

Project Management

Explore our dedicated approach to seamless project execution, guiding your molecule from early-stage R&D through to commercial-scale manufacturing with full transparency.